Anti-CHD3 antibody (1-100) [S6MR] (STJ11102316)

Name: Anti-CHD3 antibody (1-100) [S6MR] (STJ11102316)
SKU: STJ11102316
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11102316

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Short Description	Rabbit monoclonal CHD3 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S6MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CHD3
Gene ID	1107
Uniprot ID	CHD3_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MKAADTVILWARSKNDQLRI SFPPGLCWGDRMPDKDDIRL LPSALGVKKRKRGPKKQKEN KPGKPRKRKKRDSEEEFGSE RDEYREKSESGGSEYGTGPG
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHD3 (Q12873).

Tissue Specificity	Widely expressed.
Post Translational Modifications	Sumoylation at Lys-1971 results in dissociation from chromatin and suppression of transcriptional repression.
Function	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Protein Name	Chromodomain-Helicase-Dna-Binding Protein 3 Chd-3 Atp-Dependent Helicase Chd3 Mi-2 Autoantigen 240 Kda Protein Mi2-Alpha Zinc Finger Helicase Hzfh
Database Links	Reactome: R-HSA-3214815 Reactome: R-HSA-427389 Reactome: R-HSA-4551638 Reactome: R-HSA-6804758 Reactome: R-HSA-73762 Reactome: R-HSA-8943724 Reactome: R-HSA-9679191 Reactome: R-HSA-9843940 Reactome: R-HSA-9844594 Reactome: R-HSA-9845323
Cellular Localisation	Nucleus Pml Body Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Associates With Centrosomes In Interphase And Mitosis Localizes To Sites Of Dna Damage
Alternative Antibody Names	Anti-Chromodomain-Helicase-Dna-Binding Protein 3 antibody Anti-Chd-3 antibody Anti-Atp-Dependent Helicase Chd3 antibody Anti-Mi-2 Autoantigen 240 Kda Protein antibody Anti-Mi2-Alpha antibody Anti-Zinc Finger Helicase antibody Anti-Hzfh antibody Anti-CHD3 antibody

Information sourced from Uniprot.org