| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Cyclin-Dependent Kinase 12 (420-516) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4853RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK12 |
| Gene ID: |
51755 |
| Uniprot ID: |
CDK12_HUMAN |
| Immunogen Region: |
420-516 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 420-516 of human CDK12 (NP_057591.2). |
| Immunogen Sequence: |
SKGSPVFLPRKENSSVEAKD SGLESKKLPRSVKLEKSAPD TELVNVTHLNTEVKNSSDTG KVKLDENSEKHLVKDLKAQG TRDSKPIALKEEIVTPK |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation at Thr-893 increases kinase activity. |
| Function | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
| Protein Name | Cyclin-Dependent Kinase 12Cdc2-Related Kinase - Arginine/Serine-RichCrkrsCell Division Cycle 2-Related Protein Kinase 7Cdc2-Related Protein Kinase 7Cell Division Protein Kinase 12Hcdk12 |
| Database Links | Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusNucleus SpeckleColocalized With Nuclear Speckles Throughout Interphase |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 12 antibodyAnti-Cdc2-Related Kinase - Arginine/Serine-Rich antibodyAnti-Crkrs antibodyAnti-Cell Division Cycle 2-Related Protein Kinase 7 antibodyAnti-Cdc2-Related Protein Kinase 7 antibodyAnti-Cell Division Protein Kinase 12 antibodyAnti-Hcdk12 antibodyAnti-CDK12 antibodyAnti-CRK7 antibodyAnti-CRKRS antibodyAnti-KIAA0904 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
