| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Rat/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CD105 is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MEM-226 |
| Conjugation: | FITC |
| Isotype: | IgG2a |
| Formulation: | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Dilution Range: | FC 20 µl reagent/100 µl sample. |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Immunogen: | Recombinant Vaccinia virus containing the human CD105 cDNA. |
| Background | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Information sourced from Uniprot.org
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