||FOR RESEARCH USE ONLY (RUO).
||Mouse monoclonal antibody anti-CD105 is suitable for use in Flow Cytometry research applications.
||Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
||FC (20 µl reagent/100 µl sample).
||Store at 2-8°C upon receipt.
| Background || CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance