Anti-CD105 antibody [MEM-226] {FITC} (STJ16100187)

SKU:
STJ16100187-100

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Host: Mouse
Applications: FC
Reactivity: Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD105 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: MEM-226
Conjugation: FITC
Isotype: IgG2a
Formulation: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Dilution Range: FC 20 µl reagent/100 µl sample.
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Recombinant Vaccinia virus containing the human CD105 cDNA.
Background CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Information sourced from Uniprot.org

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