| Post Translational Modifications | Ubiquitinated.autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). |
| Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ccnb1ip1Cyclin-B1-Interacting Protein 1Human Enhancer Of Invasion 10Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ccnb1ip1 antibodyAnti-Cyclin-B1-Interacting Protein 1 antibodyAnti-Human Enhancer Of Invasion 10 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 antibodyAnti-CCNB1IP1 antibodyAnti-C14orf18 antibodyAnti-HEI10 antibody |
Information sourced from Uniprot.org
