Anti-CCNB1IP1 antibody (201-250 aa) (STJ93487)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CCNB1IP1 at the amino acid range 201-250
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase CCNB1IP1 (201-250 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCNB1IP1 |
| Gene ID | 57820 |
| Uniprot ID | CIP1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CCNB1IP1 at the amino acid range 201-250 |
| Immunogen Region | 201-250 aa |
| Specificity | HEI10 Polyclonal Antibody detects endogenous levels of HEI10 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). |
| Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ccnb1ip1Cyclin-B1-Interacting Protein 1Human Enhancer Of Invasion 10Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ccnb1ip1 antibodyAnti-Cyclin-B1-Interacting Protein 1 antibodyAnti-Human Enhancer Of Invasion 10 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 antibodyAnti-CCNB1IP1 antibodyAnti-C14orf18 antibodyAnti-HEI10 antibody |
Information sourced from Uniprot.org