| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase CCNB1IP1 (201-250 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNB1IP1 |
| Gene ID: | 57820 |
| Uniprot ID: | CIP1_HUMAN |
| Immunogen Region: | 201-250 aa |
| Specificity: | HEI10 Polyclonal Antibody detects endogenous levels of HEI10 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CCNB1IP1 at the amino acid range 201-250 |
| Post Translational Modifications | Ubiquitinated.autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). |
| Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ccnb1ip1 Cyclin-B1-Interacting Protein 1 Human Enhancer Of Invasion 10 Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 |
| Cellular Localisation | Nucleus Chromosome Associates To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ccnb1ip1 antibody Anti-Cyclin-B1-Interacting Protein 1 antibody Anti-Human Enhancer Of Invasion 10 antibody Anti-Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 antibody Anti-CCNB1IP1 antibody Anti-C14orf18 antibody Anti-HEI10 antibody |
Information sourced from Uniprot.org