| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASP12 |
| Gene ID: | 100506742 |
| Uniprot ID: | CASPC_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_001177945.2). |
| Immunogen Sequence: | FNNRNCQSLKDKPKVIIMQA CRGNGAGIVWFTTDSGKASA DTHGRLLQGNICNDAVTKAH VEKDFIAFKSSTPHNVSWRH ETNGSVFISQIIYYFREYSW S |
| Tissue Specificity | Widely expressed, with highest levels in lung. |
| Function | May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF. May lack protease activity (Probable). |
| Protein Name | Inactive Caspase-12Casp-12 |
| Alternative Antibody Names | Anti-Inactive Caspase-12 antibodyAnti-Casp-12 antibodyAnti-CASP12 antibodyAnti-UNQ9415 antibodyAnti-PRO34398 antibody |
Information sourced from Uniprot.org