Anti-CASP12 antibody (200-300) (STJ112891)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Caspase-12 (200-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASP12 |
| Gene ID | 100506742 |
| Uniprot ID | CASPC_HUMAN |
| Immunogen Region | 200-300 |
| Immunogen Sequence | FNNRNCQSLKDKPKVIIMQA CRGNGAGIVWFTTDSGKASA DTHGRLLQGNICNDAVTKAH VEKDFIAFKSSTPHNVSWRH ETNGSVFISQIIYYFREYSW S |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_001177945.2). |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in lung. |
| Function | May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF. May lack protease activity (Probable). |
| Protein Name | Inactive Caspase-12Casp-12 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Inactive Caspase-12 antibodyAnti-Casp-12 antibodyAnti-CASP12 antibodyAnti-UNQ9415 antibodyAnti-PRO34398 antibody |
Information sourced from Uniprot.org