| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C1R |
| Gene ID: | 715 |
| Uniprot ID: | C1R_HUMAN |
| Immunogen Region: | 466-705 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3). |
| Immunogen Sequence: | GGQKAKMGNFPWQVFTNIHG RGGGALLGDRWILTAAHTLY PKEHEAQSNASLDVFLGHTN VEELMKLGNHPIRRVSVHPD YRQDESYNFEGDIALLELEN SVTLGPNLLPICLPDNDTFY DLGLMGYVSGFGVMEEKIAH DLRFVRLPVANPQACENWLR GKNRMDVFSQNMFCAGHPSL KQDACQGDSGGVFAVRDPNT DRWVATGIVSWGIGCSRGYG FYTKVLNYVDWIKKEMEEE |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. |
| Protein Name | Complement C1r Subcomponent Complement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain |
| Database Links | Reactome: R-HSA-166663 Reactome: R-HSA-173623 Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement C1r Subcomponent antibody Anti-Complement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain antibody Anti-C1R antibody |
Information sourced from Uniprot.org