| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C1R (466-705) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
C1R |
| Gene ID: |
715 |
| Uniprot ID: |
C1R_HUMAN |
| Immunogen Region: |
466-705 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3). |
| Immunogen Sequence: |
GGQKAKMGNFPWQVFTNIHG RGGGALLGDRWILTAAHTLY PKEHEAQSNASLDVFLGHTN VEELMKLGNHPIRRVSVHPD YRQDESYNFEGDIALLELEN SVTLGPNLLPICLPDNDTFY DLGLMGYVSGFGVMEEKIAH DLRFVRLPVANPQACENWLR GKNRMDVFSQNMFCAGHPSL KQDACQGDSGGVFAVRDPNT DRWVATGIVSWGIGCSRGYG FYTKVLNYVDWIKKEMEEE |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. |
| Protein Name | Complement C1r SubcomponentComplement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement C1r Subcomponent antibodyAnti-Complement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain antibodyAnti-C1R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
