| Short Description : | Rabbit polyclonal BTBD7 (5-75) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BTBD7 |
| Gene ID: | 55727 |
| Uniprot ID: | BTBD7_HUMAN |
| Immunogen Region: | 5-75 |
| Immunogen Sequence: | ASNYPHSCSPRVGGNSQAQQ TFIGTSSYSQQGYGCESKLY SLDHGHEKPQDKKKRTSGLA TLKKKFIKRRK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 5-75 of human BTBD7 (NP_060637.1). |
| Function | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. |
| Protein Name | Btb/Poz Domain-Containing Protein 7 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein 7 antibodyAnti-BTBD7 antibodyAnti-KIAA1525 antibody |
Information sourced from Uniprot.org
