Anti-BTBD7 antibody (5-75) (STJ11100164)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BTBD7 (5-75) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BTBD7 |
| Gene ID | 55727 |
| Uniprot ID | BTBD7_HUMAN |
| Immunogen Region | 5-75 |
| Immunogen Sequence | ASNYPHSCSPRVGGNSQAQQ TFIGTSSYSQQGYGCESKLY SLDHGHEKPQDKKKRTSGLA TLKKKFIKRRK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 5-75 of human BTBD7 (NP_060637.1). |
Additional Info
| Function | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. |
| Protein Name | Btb/Poz Domain-Containing Protein 7 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein 7 antibodyAnti-BTBD7 antibodyAnti-KIAA1525 antibody |
Information sourced from Uniprot.org