| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BMP10 |
| Gene ID: | 27302 |
| Uniprot ID: | BMP10_HUMAN |
| Immunogen Region: | 22-316 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). |
| Immunogen Sequence: | SPIMNLEQSPLEEDMSLFGD VFSEQDGVDFNTLLQSMKDE FLKTLNLSDIPTQDSAKVDP PEYMLELYNKFATDRTSMPS ANIIRSFKNEDLFSQPVSFN GLRKYPLLFNVSIPHHEEVI MAELRLYTLVQRDRMIYDGV DRKITIFEVLESKGDNEGER NMLVLVSGEIYGTNSEWETF DVTDAIRRWQKSGSSTHQLE VHIESKHDEAEDASSGRLEI DTSAQNKHNPLLIVFSDDQ |
| Tissue Specificity | Detected in mammary epithelia (at protein level). |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Protein Name | Bone Morphogenetic Protein 10Bmp-10 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 10 antibodyAnti-Bmp-10 antibodyAnti-BMP10 antibody |
Information sourced from Uniprot.org
