Anti-BMP10 antibody (22-316) (STJ117205)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMP10 (22-316) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP10 |
| Gene ID | 27302 |
| Uniprot ID | BMP10_HUMAN |
| Immunogen Region | 22-316 |
| Immunogen Sequence | SPIMNLEQSPLEEDMSLFGD VFSEQDGVDFNTLLQSMKDE FLKTLNLSDIPTQDSAKVDP PEYMLELYNKFATDRTSMPS ANIIRSFKNEDLFSQPVSFN GLRKYPLLFNVSIPHHEEVI MAELRLYTLVQRDRMIYDGV DRKITIFEVLESKGDNEGER NMLVLVSGEIYGTNSEWETF DVTDAIRRWQKSGSSTHQLE VHIESKHDEAEDASSGRLEI DTSAQNKHNPLLIVFSDDQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). |
Additional Info
| Tissue Specificity | Detected in mammary epithelia (at protein level). |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Protein Name | Bone Morphogenetic Protein 10Bmp-10 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 10 antibodyAnti-Bmp-10 antibodyAnti-BMP10 antibody |
Information sourced from Uniprot.org