| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BMP10 (22-316) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BMP10 |
| Gene ID: |
27302 |
| Uniprot ID: |
BMP10_HUMAN |
| Immunogen Region: |
22-316 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). |
| Immunogen Sequence: |
SPIMNLEQSPLEEDMSLFGD VFSEQDGVDFNTLLQSMKDE FLKTLNLSDIPTQDSAKVDP PEYMLELYNKFATDRTSMPS ANIIRSFKNEDLFSQPVSFN GLRKYPLLFNVSIPHHEEVI MAELRLYTLVQRDRMIYDGV DRKITIFEVLESKGDNEGER NMLVLVSGEIYGTNSEWETF DVTDAIRRWQKSGSSTHQLE VHIESKHDEAEDASSGRLEI DTSAQNKHNPLLIVFSDDQ |
| Tissue Specificity | Detected in mammary epithelia (at protein level). |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Protein Name | Bone Morphogenetic Protein 10Bmp-10 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 10 antibodyAnti-Bmp-10 antibodyAnti-BMP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
