| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP6AP1 (90-390) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATP6AP1 |
| Gene ID: |
537 |
| Uniprot ID: |
VAS1_HUMAN |
| Immunogen Region: |
90-390 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-390 of human ATP6AP1 (NP_001174.2). |
| Immunogen Sequence: |
LLFLQDKLSIEDFTAYGGVF GNKQDSAFSNLENALDLAPS SLVLPAVDWYAVSTLTTYLQ EKLGASPLHVDLATLRELKL NASLPALLLIRLPYTASSGL MAPREVLTGNDEVIGQVLST LKSEDVPYTAALTAVRPSRV ARDVAVVAGGLGRQLLQKQP VSPVIHPPVSYNDTAPRILF WAQNFSVAYKDQWEDLTPLT FGVQELNLTGSFWNDSFARL SLTYERLFGTTVTFKFILA |
| Tissue Specificity | widely expressed, with highest levels in brain and lowest in liver and duodenum. |
| Post Translational Modifications | N-glycosylated. |
| Function | Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex (Probable). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules. |
| Protein Name | V-Type Proton Atpase Subunit S1V-Atpase Subunit S1Protein Xap-3V-Atpase Ac45 SubunitV-Atpase S1 Accessory ProteinVacuolar Proton Pump Subunit S1 |
| Database Links | Reactome: R-HSA-77387Reactome: R-HSA-8980692Reactome: R-HSA-917977Reactome: R-HSA-983712 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneClathrin-Coated Vesicle MembraneNot Detected In Trans-Golgi Network |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Subunit S1 antibodyAnti-V-Atpase Subunit S1 antibodyAnti-Protein Xap-3 antibodyAnti-V-Atpase Ac45 Subunit antibodyAnti-V-Atpase S1 Accessory Protein antibodyAnti-Vacuolar Proton Pump Subunit S1 antibodyAnti-ATP6AP1 antibodyAnti-ATP6IP1 antibodyAnti-ATP6S1 antibodyAnti-VATPS1 antibodyAnti-XAP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
