| Tissue Specificity | widely expressed, with highest levels in brain and lowest in liver and duodenum. |
| Post Translational Modifications | N-glycosylated. |
| Function | Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex (Probable). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules. |
| Protein Name | V-Type Proton Atpase Subunit S1V-Atpase Subunit S1Protein Xap-3V-Atpase Ac45 SubunitV-Atpase S1 Accessory ProteinVacuolar Proton Pump Subunit S1 |
| Database Links | Reactome: R-HSA-77387Reactome: R-HSA-8980692Reactome: R-HSA-917977Reactome: R-HSA-983712 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneClathrin-Coated Vesicle MembraneNot Detected In Trans-Golgi Network |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Subunit S1 antibodyAnti-V-Atpase Subunit S1 antibodyAnti-Protein Xap-3 antibodyAnti-V-Atpase Ac45 Subunit antibodyAnti-V-Atpase S1 Accessory Protein antibodyAnti-Vacuolar Proton Pump Subunit S1 antibodyAnti-ATP6AP1 antibodyAnti-ATP6IP1 antibodyAnti-ATP6S1 antibodyAnti-VATPS1 antibodyAnti-XAP3 antibody |
Information sourced from Uniprot.org
