Anti-Artemin antibody [2D12] (STJA0002897)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant human Artemin protein produced using CHO-based proprietary suspension cell line. Immunogen is purified from cell culture supernatant. Human Artemin
General Information
| Short Description | Mouse monoclonal anti-Artemin for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2D12 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein G purification |
| Dilution Range | ELISA 0.2 to 2 ยตg/ml; WB 0.5 to 2 ยตg/ml (detects only dimeric protein in non-reducing conditions) ; IF 0.3 to 20 ยตg/ml. Monoclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Formulation | PBS pH 7.4, with 0.1% sodium azide |
| Storage Instruction | Store at-20 to-70ยฐC upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles |
Target Information
| Gene Symbol | ARTN |
| Gene ID | 9048 |
| Uniprot ID | ARTN_HUMAN |
| Immunogen | Recombinant human Artemin protein produced using CHO-based proprietary suspension cell line. Immunogen is purified from cell culture supernatant. Human Artemin |
| Specificity | Human Artemin |
Additional Info
| Tissue Specificity | Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. |
| Function | Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. |
| Protein Name | ArteminEnovinNeublastin |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Artemin antibodyAnti-Enovin antibodyAnti-Neublastin antibodyAnti-ARTN antibodyAnti-EVN antibody |
Information sourced from Uniprot.org