Host: | Mouse |
Applications: | ELISA/WB/IF |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-Artemin is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
Clonality : | Monoclonal |
Clone ID : | 2D12 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | PBS pH 7.4, with 0.1% sodium azide |
Purification: | Protein G purification |
Dilution Range: | ELISA 0.2 to 2 µg/ml; WB 0.5 to 2 µg/ml (detects only dimeric protein in non-reducing conditions) ; IF 0.3 to 20 µg/ml. Monoclonal antibody working titer has to be established practically for each particular antigen and assay format |
Storage Instruction: | Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles |
Gene Symbol: | ARTN |
Gene ID: | 9048 |
Uniprot ID: | ARTN_HUMAN |
Specificity: | Human Artemin |
Immunogen: | Recombinant human Artemin protein produced using CHO-based proprietary suspension cell line. Immunogen is purified from cell culture supernatant. Human Artemin |
Tissue Specificity | Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. |
Function | Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. |
Protein Name | ArteminEnovinNeublastin |
Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Artemin antibodyAnti-Enovin antibodyAnti-Neublastin antibodyAnti-ARTN antibodyAnti-EVN antibody |
Information sourced from Uniprot.org