Anti-APAF1 antibody (470-600) (STJ117996)

Name: Anti-APAF1 antibody (470-600) (STJ117996)
SKU: STJ117996
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117996

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Short Description	Rabbit polyclonal APAF1 (470-600) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	APAF1
Gene ID	317
Uniprot ID	APAF_HUMAN
Immunogen Region	470-600
Immunogen Sequence	PHTLSPDQEDCMYWYNFLAY HMASAKMHKELCALMFSLDW IKAKTELVGPAHLIHEFVEY RHILDEKDCAVSENFQEFLS LNGHLLGRQPFPNIVQLGLC EPETSEVYQQAKLQAKQEVD NGMLYLEWINK
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 470-600 of human APAF1 (NP_863651.1).

Tissue Specificity	Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Function	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Protein Name	Apoptotic Protease-Activating Factor 1 Apaf-1
Database Links	Reactome: R-HSA-111458 Reactome: R-HSA-111459 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-6798695 Reactome: R-HSA-6803207 Reactome: R-HSA-8953750 Reactome: R-HSA-9627069
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Apoptotic Protease-Activating Factor 1 antibody Anti-Apaf-1 antibody Anti-APAF1 antibody Anti-KIAA0413 antibody

Information sourced from Uniprot.org