Anti-APAF1 antibody (470-600) (STJ117996)

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STJ117996
€132.60 - €606.60
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Short Description :Rabbit polyclonal APAF1 (470-600) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IF/ICC/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:APAF1
Gene ID:317
Uniprot ID:APAF_HUMAN
Immunogen Region:470-600
Immunogen Sequence:PHTLSPDQEDCMYWYNFLAY HMASAKMHKELCALMFSLDW IKAKTELVGPAHLIHEFVEY RHILDEKDCAVSENFQEFLS LNGHLLGRQPFPNIVQLGLC EPETSEVYQQAKLQAKQEVD NGMLYLEWINK
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 470-600 of human APAF1 (NP_863651.1).
Tissue Specificity Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Protein Name Apoptotic Protease-Activating Factor 1
Apaf-1
Database Links Reactome: R-HSA-111458
Reactome: R-HSA-111459
Reactome: R-HSA-111463
Reactome: R-HSA-111464
Reactome: R-HSA-6798695
Reactome: R-HSA-6803207
Reactome: R-HSA-8953750
Reactome: R-HSA-9627069
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Apoptotic Protease-Activating Factor 1 antibody
Anti-Apaf-1 antibody
Anti-APAF1 antibody
Anti-KIAA0413 antibody

Information sourced from Uniprot.org