| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. |
| Post Translational Modifications | N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan.contains chondroitin sulfate. May be cleaved by a furin endopeptidase. The precursor is sequentially processed. |
| Function | Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7Adam-Ts 7Adam-Ts7Adamts-7 |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixAlso Found Associated With The External Cell Surface |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 antibodyAnti-Adam-Ts 7 antibodyAnti-Adam-Ts7 antibodyAnti-Adamts-7 antibodyAnti-ADAMTS7 antibody |
Information sourced from Uniprot.org
