Anti-ADAMTS7 antibody (1600-1686) (STJ11101204)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAMTS7 (1600-1686) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAMTS7 |
| Gene ID | 11173 |
| Uniprot ID | ATS7_HUMAN |
| Immunogen Region | 1600-1686 |
| Immunogen Sequence | QTGLPEEDSDQCGHEAWPES SRPCGTEDCEPVEPPRCERD RLSFGFCETLRLLGRCQLPT IRTQCCRSCSPPSHGAPSRG HQRVARR |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2). |
Additional Info
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. |
| Post Translational Modifications | N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan.contains chondroitin sulfate. May be cleaved by a furin endopeptidase. The precursor is sequentially processed. |
| Function | Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7Adam-Ts 7Adam-Ts7Adamts-7 |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixAlso Found Associated With The External Cell Surface |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 antibodyAnti-Adam-Ts 7 antibodyAnti-Adam-Ts7 antibodyAnti-Adamts-7 antibodyAnti-ADAMTS7 antibody |
Information sourced from Uniprot.org