| Function | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity. |
| Protein Name | Fatty Acid Coa Ligase Acsl3Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 3Lacs 3Long-Chain-Fatty-Acid--Coa Ligase 3Medium-Chain Acyl-Coa Ligase Acsl3 |
| Database Links | Reactome: R-HSA-434313Reactome: R-HSA-75876 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinPeroxisome MembraneMicrosome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Fatty Acid Coa Ligase Acsl3 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 3 antibodyAnti-Lacs 3 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase 3 antibodyAnti-Medium-Chain Acyl-Coa Ligase Acsl3 antibodyAnti-ACSL3 antibodyAnti-ACS3 antibodyAnti-FACL3 antibodyAnti-LACS3 antibody |
Information sourced from Uniprot.org
