Anti-AAAS antibody (287-546) (STJ28510)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AAAS (287-546) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AAAS |
| Gene ID | 8086 |
| Uniprot ID | AAAS_HUMAN |
| Immunogen Region | 287-546 |
| Immunogen Sequence | GGGVTNLLWSPDGSKILATT PSAVFRVWEAQMWTCERWPT LSGRCQTGCWSPDGSRLLFT VLGEPLIYSLSFPERCGEGK GCVGGAKSATIVADLSETTI QTPDGEERLGGEAHSMVWDP SGERLAVLMKGKPRVQDGKP VILLFRTRNSPVFELLPCGI IQGEPGAQPQLITFHPSFNK GALLSVGWSTGRIAHIPLYF VNAQFPRFSPVLGRAQEPPA GGGGSIHDLPLFTETSPTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 287-546 of human AAAS (NP_056480.1). |
Additional Info
| Tissue Specificity | Widely expressed. Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung. |
| Function | Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment. |
| Protein Name | AladinAdracalin |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-8980692Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmCytoskeletonSpindle PoleNucleus EnvelopeIn Metaphase Cells Localizes Within The Spindle With Some Accumulation Around Spindle PolesWith The Highest Concentration Between The Centrosome And Metaphase PlateThe Localization To The Spindle Is Microtubule-Mediated |
| Alternative Antibody Names | Anti-Aladin antibodyAnti-Adracalin antibodyAnti-AAAS antibodyAnti-ADRACALA antibodyAnti-GL003 antibody |
Information sourced from Uniprot.org