| Host: | Rabbit |
| Applications: | WB, IF |
| Reactivity: | Human |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Short Description: | Rabbit polyclonal antibody anti-AAAS (287-546) is suitable for use in Western Blot and Immunofluorescence. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF 1:50-1:200 |
| Storage Instruction: | Store in a freezer at-20°C and avoid freeze-thaw cycles. |
| Gene Symbol: | AAAS |
| Gene ID: | 8086 |
| Uniprot ID: | AAAS_HUMAN |
| Immunogen Region: | 287-546 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-546 of human AAAS (NP_056480.1). |
| Tissue Specificity | Widely expressed. Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung. |
| Function | Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment. |
| Protein Name | AladinAdracalin |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-8980692Reactome: R-HSA-9609690Reactome: R-HSA-9610379 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmCytoskeletonSpindle PoleNucleus EnvelopeIn Metaphase Cells Localizes Within The Spindle With Some Accumulation Around Spindle PolesWith The Highest Concentration Between The Centrosome And Metaphase PlateThe Localization To The Spindle Is Microtubule-Mediated |
| Alternative Antibody Names | Anti-Aladin antibodyAnti-Adracalin antibodyAnti-AAAS antibodyAnti-ADRACALA antibodyAnti-GL003 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
