| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-AAAS (287-546) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AAAS |
| Gene ID: | 8086 |
| Uniprot ID: | AAAS_HUMAN |
| Immunogen Region: | 287-546 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-546 of human AAAS (NP_056480.1). |
| Immunogen Sequence: | GGGVTNLLWSPDGSKILATT PSAVFRVWEAQMWTCERWPT LSGRCQTGCWSPDGSRLLFT VLGEPLIYSLSFPERCGEGK GCVGGAKSATIVADLSETTI QTPDGEERLGGEAHSMVWDP SGERLAVLMKGKPRVQDGKP VILLFRTRNSPVFELLPCGI IQGEPGAQPQLITFHPSFNK GALLSVGWSTGRIAHIPLYF VNAQFPRFSPVLGRAQEPPA GGGGSIHDLPLFTETSPTS |
| Tissue Specificity | Widely expressed. Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung. |
| Function | Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment. |
| Protein Name | AladinAdracalin |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-8980692Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmCytoskeletonSpindle PoleNucleus EnvelopeIn Metaphase Cells Localizes Within The Spindle With Some Accumulation Around Spindle PolesWith The Highest Concentration Between The Centrosome And Metaphase PlateThe Localization To The Spindle Is Microtubule-Mediated |
| Alternative Antibody Names | Anti-Aladin antibodyAnti-Adracalin antibodyAnti-AAAS antibodyAnti-ADRACALA antibodyAnti-GL003 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
