| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SLC7A10 Blocking Peptide for STJ500165 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Slc7a10 |
| Gene ID: |
53896 |
| Uniprot ID: |
AAA1_MOUSE |
| Immunogen Region: |
1-50 |
| Specificity: |
This blocking peptide is recommended for use in combination with SLC7A10 antibody, STJ500165 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-50 on rat Asc-type amino acid transporter 1 protein. |
| Tissue Specificity | Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine. Expressed in a subpopulation of astrocytes enriched at glycinergic synapses in the spinal cord and brainstem (at protein level). Expressed in OLIG2-positive astrocytes of the lateral globus pallidus (at protein level). Expressed in CD34-positive, DPP4-positive mesenchymal progenitors in developing subcutaneous adipose tissue. |
| Function | Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment. |
| Peptide Name | Asc-Type Amino Acid Transporter 1Asc-1D-Serine TransporterSolute Carrier Family 7 Member 10 |
| Database Links | Reactome: R-MMU-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes |
| Alternative Peptide Names | Asc-Type Amino Acid Transporter 1 proteinAsc-1 proteinD-Serine Transporter proteinSolute Carrier Family 7 Member 10 proteinSlc7a10 proteinAsc1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
