SLC7A10 Blocking Peptide for STJ500165 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 1-50 on rat Asc-type amino acid transporter 1 protein.
Immunogen Region
1-50
Specificity
This blocking peptide is recommended for use in combination with SLC7A10 antibody, STJ500165
Additional Info
Tissue Specificity
Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine. Expressed in a subpopulation of astrocytes enriched at glycinergic synapses in the spinal cord and brainstem (at protein level). Expressed in OLIG2-positive astrocytes of the lateral globus pallidus (at protein level). Expressed in CD34-positive, DPP4-positive mesenchymal progenitors in developing subcutaneous adipose tissue.
Function
Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment.
Peptide Name
Asc-Type Amino Acid Transporter 1Asc-1D-Serine TransporterSolute Carrier Family 7 Member 10
Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes
Alternative Peptide Names
Asc-Type Amino Acid Transporter 1 proteinAsc-1 proteinD-Serine Transporter proteinSolute Carrier Family 7 Member 10 proteinSlc7a10 proteinAsc1 protein
