SLC26A3 Positive Control for STJ506235 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
WB
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
This is positive control is recommended for use in combination with SLC26A3 antibody STJ506235.
Additional Info
Tissue Specificity
Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Post Translational Modifications
N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.
Function
Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Peptide Name
Chloride Anion ExchangerDown-Regulated In AdenomaProtein DraSolute Carrier Family 26 Member 3
Apical Cell MembraneMulti-Pass Membrane ProteinMembraneCell MembraneLocalized In Sperm MembranesMidpiece Of Sperm TailColocalizes With Cftr At The Midpiece Of Sperm Tail
Alternative Peptide Names
Chloride Anion Exchanger proteinDown-Regulated In Adenoma proteinProtein Dra proteinSolute Carrier Family 26 Member 3 proteinSLC26A3 proteinDRA protein
