| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SLC26A3 Positive Control for STJ506235 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SLC26A3 |
| Gene ID: |
1811 |
| Uniprot ID: |
S26A3_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with SLC26A3 antibody STJ506235. |
| Tissue Specificity | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. |
| Post Translational Modifications | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Peptide Name | Chloride Anion ExchangerDown-Regulated In AdenomaProtein DraSolute Carrier Family 26 Member 3 |
| Database Links | Reactome: R-HSA-427601Reactome: R-HSA-5619085 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinMembraneCell MembraneLocalized In Sperm MembranesMidpiece Of Sperm TailColocalizes With Cftr At The Midpiece Of Sperm Tail |
| Alternative Peptide Names | Chloride Anion Exchanger proteinDown-Regulated In Adenoma proteinProtein Dra proteinSolute Carrier Family 26 Member 3 proteinSLC26A3 proteinDRA protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
