Rat sCD14 (sCD14) Antibody Pair (STJAP00938)
SPECIFICATIONS
HostRabbit/Rabbit
ConjugationUnconjugated/Biotin
General Information
| Short Description | This sCD14 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL/0.5-4ug/mL |
| Dilution Range | 1:1000-1:10000 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Detection | Colorimetric method;ELISA;Sandwich |
Target Information
| Gene Symbol | Cd14 |
| Gene ID | 60350 |
| Uniprot ID | CD14_RAT |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). |
| Protein Name | Monocyte Differentiation Antigen Cd14Myeloid Cell-Specific Leucine-Rich GlycoproteinCd Antigen Cd14 |
| Database Links | Reactome: R-RNO-140534Reactome: -RNO-166016Reactome: -RNO-166020Reactome: -RNO-166166Reactome: -RNO-2562578Reactome: -RNO-5686938Reactome: -RNO-6798695Reactome: -RNO-936964Reactome: -RNO-937041Reactome: -RNO-937072Reactome: -RNO-975163Reactome: -RNO-9824878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedMembrane RaftGolgi ApparatusSolubleSecreted Forms Seem To ExistThey May Arise By Cleavage Of The Gpi Anchor |
| Alternative Antibody Pair Names | Monocyte Differentiation Antigen Cd14 antibody pairMyeloid Cell-Specific Leucine-Rich Glycoprotein antibody pairCd Antigen Cd14 antibody pairCd14 antibody pair |
Information sourced from Uniprot.org