Rat DIO1 (Deiodinase, Iodothyronine, Type I) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014813)
SPECIFICATIONS
General Information
| Short Description | This DIO1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 0.059ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Dio1 |
| Gene ID | 25430 |
| Uniprot ID | IOD1_RAT |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Highly expressed in the liver, kidney and thyroid gland. |
| Post Translational Modifications | |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine. Catalyzes the deiodination of T3 and 3,3',5-triiodo-L-thyronine sulfate via IRD. Catalyzes the deiodination of L-thyroxine sulfate via IRD and 3,3',5'-triiodo-L-thyronine sulfate via ORD. |
| Protein Name | Type I Iodothyronine Deiodinase5diDioiType 1 DiType-I 5'-Deiodinase |
| Database Links | Reactome: R-RNO-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinEndoplasmic Reticulum MembraneBasolateral Cell Membrane |
| Alternative ELISA Names | Type I Iodothyronine Deiodinase ELISA kit5di ELISA kitDioi ELISA kitType 1 Di ELISA kitType-I 5'-Deiodinase ELISA kitDio1 ELISA kitItdi1 ELISA kitTxdi1 ELISA kit |
| output |
Information sourced from Uniprot.org