| Tissue Specificity | Highly expressed in the liver, kidney and thyroid gland. |
| Post Translational Modifications | |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine. Catalyzes the deiodination of T3 and 3,3',5-triiodo-L-thyronine sulfate via IRD. Catalyzes the deiodination of L-thyroxine sulfate via IRD and 3,3',5'-triiodo-L-thyronine sulfate via ORD. |
| Protein Name | Type I Iodothyronine Deiodinase5diDioiType 1 DiType-I 5'-Deiodinase |
| Database Links | Reactome: R-RNO-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinEndoplasmic Reticulum MembraneBasolateral Cell Membrane |
| Alternative ELISA Names | Type I Iodothyronine Deiodinase ELISA kit5di ELISA kitDioi ELISA kitType 1 Di ELISA kitType-I 5'-Deiodinase ELISA kitDio1 ELISA kitItdi1 ELISA kitTxdi1 ELISA kit |
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Information sourced from Uniprot.org
