Cell Surface Proteins
Cell surface proteins in this range are recombinant human receptors, ligands and CD markers, produced mainly as the extracellular domain (ECD) of the native protein. Expression is carried out predominantly in HEK293 cells, with further targets produced in CHO cells, insect cells or P.pastoris. Products are supplied unconjugated, with an untagged or Fc-tagged format available for selected targets.
Browse Cell Surface ProteinsTwo Receptors With Functional Validation Data
CD137 (4-1BB) and CXCR4 were chosen for the functional validation data supplied on their own product datasheets, going beyond a purity gel to show the protein performing in a cell-based assay. Both are recombinant extracellular domain constructs expressed in mammalian cells and supplied unconjugated.
Human 4-1BB (CD137) Protein (STJP000593)
4-1BB (CD137) is an inducible costimulatory receptor of the TNF receptor superfamily, expressed on activated T cells and NK cells. This CHO-expressed protein has been used to coat assay plates for a microglial cell attachment study, where plates coated with 4-1BB-Fc showed increased microglial binding compared to an Fc control, supporting its use as a functional coating reagent rather than a purity-only reference standard.
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Human CXCR4 Protein (STJP000572)
CXCR4 is a chemokine receptor central to leukocyte trafficking, binding its ligand CXCL12 to direct cell migration. The datasheet for this HEK293-expressed protein references a study in which activated dendritic cells upregulated the migratory receptors CCR7 and CXCR4 and showed increased chemotactic responsiveness to their ligands CCL19 and CXCL12, tying the recombinant protein to a documented migration assay.
View product →Cell Surface Proteins for Immune Costimulation Research
Recombinant receptors involved in T cell activation and regulatory T cell identity. The range includes 4-1BB (CD137), a TNF receptor superfamily costimulatory receptor upregulated on activated T and NK cells, the CD3 epsilon-delta heterodimer, part of the T cell receptor complex responsible for signal transduction following antigen recognition, and CD25 (IL2RA), the high-affinity IL-2 receptor alpha chain used as a marker of regulatory T cells and recently activated effector T cells. These targets are used together in studies of T cell priming and activation status.
Cell Surface Proteins for Cytokine Receptor Research
Recombinant receptor subunits for cytokines that drive inflammatory and lymphocyte signalling. The range covers the IL-6 receptor (IL-6R), which pairs with gp130 to transduce IL-6 signalling and is the basis of IL-6R-blocking research strategies, IL-1 receptor 1 (CD121a), the signalling receptor for IL-1 beta, and IL-21R (CD360), a type I cytokine receptor expressed on lymphocytes. These receptor targets are used to dissect how individual cytokines engage their signalling complexes and how receptor blockade affects downstream cellular responses.
Cell Surface Proteins for Chemokine and Immune Receptor Research
Recombinant receptors used in cell migration and viral entry research. CXCR4 is a chemokine receptor central to leukocyte trafficking and stem cell homing, directing cell migration in response to its ligand CXCL12. Soluble CD4 is the extracellular portion of the primary HIV entry receptor on T helper cells, used to study receptor engagement in viral entry research. These two targets support work spanning cell migration assays and receptor-ligand binding studies.
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Browse the full range of recombinant CD markers, receptors and ligands, or contact us if a specific target is not listed.
Browse Cell Surface Proteins