Human IL2RA (CD25) protein (Recombinant) (STJP000332)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of human CD25 including a C-terminal polyHis tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human IL2RA (CD25)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | 0.2 Mu m filtered PBS solution, pH7.4. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity of recombinant IL-2Ra (CD25) was determined by its ability to bind Human IL-2 with an affinity constant of 30nM. NA |
Target Information
| Gene Symbol | IL2RA |
| Gene ID | 3559 |
| Uniprot ID | IL2RA_HUMAN |
| Immunogen | Optimized DNA sequence encoding extracellular domain of human CD25 including a C-terminal polyHis tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Function | Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
| Protein Name | Interleukin-2 Receptor Subunit AlphaIl-2 Receptor Subunit AlphaIl-2-RaIl-2r Subunit AlphaIl2-RaTac AntigenP55Cd Antigen Cd25 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8877330Reactome: R-HSA-9020558Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-2 Receptor Subunit Alpha proteinIl-2 Receptor Subunit Alpha proteinIl-2-Ra proteinIl-2r Subunit Alpha proteinIl2-Ra proteinTac Antigen proteinP55 proteinCd Antigen Cd25 proteinIL2RA protein |
Information sourced from Uniprot.org