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Primary Antibodies
IHC Guaranteed Antibodies
Validated by direct immunohistochemical staining on FFPE tissue.Primary antibodies validated for immunohistochemistry (IHC), each backed by a performance guarantee for detecting target proteins with high specificity in the applicable reactive species.
How it works
From tissue section to visible signal
Immunohistochemistry detects a target protein in situ within a formalin-fixed, paraffin-embedded (FFPE) tissue section, producing a visible signal at the site of antibody binding. Antibody performance is application-specific: fixation, epitope accessibility and tissue architecture in IHC differ from the conditions in western blot or ELISA, so each antibody in this range has been validated by direct immunohistochemical staining rather than inferred from another application.
Category benefits
Why use IHC Guaranteed antibodies?
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Removes IHC optimisation guesswork Each antibody has already been through IHC-specific validation, so researchers can move directly into their experiment instead of first determining whether an antibody validated for another application will perform on tissue. |
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Positive control data included Each antibody is tested against positive control tissue, with the staining result published directly on the product datasheet. |
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Backed by a product guarantee Each antibody is guaranteed to meet the specifications on its product datasheet. If a product falls outside those stated performance criteria, our technical support team will work to resolve the issue, and qualifying products are eligible for replacement or refund. |
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Antibody choice matched to your model With 3,497 antibodies spanning six host species (mouse, rabbit, rat, human, guinea pig and goat) and both monoclonal (3,292) and polyclonal (201) formats, researchers can select a host and clonality suited to their tissue model, and avoid host overlap when co-staining with other markers. Filterable by host and clonality on the product listing. |
Where they're used
Typical applications
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Tumour biomarker research IHC is used to assess oncogenic biomarkers such as HER2, PD-L1 and Ki-67 in cancer research, scoring their expression directly in tumour tissue sections. |
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Target expression profiling in drug discovery Tissue microarrays stained by IHC are used in drug discovery pathology to determine how a novel target molecule is distributed across organs and tissue types. |
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Biomarker panel development IHC-based screening across tissue microarrays supports the development of biomarker panels, used to study protein expression patterns associated with disease progression in research models. |
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Subcellular localisation and pathway studies Beyond detecting whether a target is present, IHC is used to assess whether it localises to the nucleus, cytoplasm or cell membrane, information used in tissue-based pathway studies. |
Choosing an IHC Guaranteed antibody for a specific target
The technical support team is available to help select an antibody for a given target. Every product page includes a downloadable datasheet and SDS, with dispatch on overnight priority shipping with gel ice packs.
Looking for more primary antibodies?See the full range of polyclonal, monoclonal and recombinant primary antibodies, filterable by application, host and target. |
Visit the primary antibodies hub |
For Research Use Only. Not for use in diagnostic procedures.