| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PI3R6 Positive Control for STJ506052 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PIK3R6 |
| Gene ID: |
146850 |
| Uniprot ID: |
PI3R6_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with PI3R6 antibody STJ506052. |
| Immunogen: |
Purified protein. |
| Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis.signaling seems to involve RRAS. |
| Peptide Name | Phosphoinositide 3-Kinase Regulatory Subunit 6Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KdaP84 Pi3k Adapter ProteinP84 PikapP87 Pi3k Adapter ProteinP87pikap |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1660499Reactome: R-HSA-392451 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinTranslocated To The Plasma Membrane In A Ras-Dependent Manner |
| Alternative Peptide Names | Phosphoinositide 3-Kinase Regulatory Subunit 6 proteinPhosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda proteinP84 Pi3k Adapter Protein proteinP84 Pikap proteinP87 Pi3k Adapter Protein proteinP87pikap proteinPIK3R6 proteinC17orf38 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
