PI3R6 Positive Control for STJ506052 peptide (STJ505799)

SKU:
STJ505799-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PI3R6 Positive Control for STJ506052 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PIK3R6
Gene ID: 146850
Uniprot ID: PI3R6_HUMAN
Specificity: This is positive control is recommended for use in combination with PI3R6 antibody STJ506052.
Immunogen: Purified protein.
Function Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis.signaling seems to involve RRAS.
Peptide Name Phosphoinositide 3-Kinase Regulatory Subunit 6
Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda
P84 Pi3k Adapter Protein
P84 Pikap
P87 Pi3k Adapter Protein
P87pikap
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-1660499
Reactome: R-HSA-392451
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Translocated To The Plasma Membrane In A Ras-Dependent Manner
Alternative Peptide Names Phosphoinositide 3-Kinase Regulatory Subunit 6 protein
Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda protein
P84 Pi3k Adapter Protein protein
P84 Pikap protein
P87 Pi3k Adapter Protein protein
P87pikap protein
PIK3R6 protein
C17orf38 protein

Information sourced from Uniprot.org

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