PDE12 Blocking Peptide for STJ502225 peptide (STJ505305)

SKU:
STJ505305-250
$380.03
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PDE12 Blocking Peptide for STJ502225 is synthetically produced from the 570-620 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE12
Gene ID: 201626
Uniprot ID: PDE12_HUMAN
Immunogen Region: 570-620
Specificity: This blocking peptide is recommended for use in combination with PDE12 antibody, STJ502225
Immunogen: Synthetic peptide taken within amino acid region 570-620 on human PDE12A protein.
Tissue Specificity Ubiquitous.
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.
Peptide Name 2' -5'-Phosphodiesterase 12
2'-Pde
2-Pde
Mitochondrial Deadenylase
Database Links Reactome: R-HSA-8983711
Cellular Localisation Mitochondrion Matrix
Alternative Peptide Names 2' -5'-Phosphodiesterase 12 protein
2'-Pde protein
2-Pde protein
Mitochondrial Deadenylase protein
PDE12 protein

Information sourced from Uniprot.org

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