PDE12 Blocking Peptide for STJ502225 peptide (STJ505305)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 570-620 on human PDE12A protein.
General Information
| Short Description | PDE12 Blocking Peptide for STJ502225 is synthetically produced from the 570-620 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE12 |
| Gene ID | 201626 |
| Uniprot ID | PDE12_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 570-620 on human PDE12A protein. |
| Immunogen Region | 570-620 |
| Specificity | This blocking peptide is recommended for use in combination with PDE12 antibody, STJ502225 |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. |
| Peptide Name | 2' -5'-Phosphodiesterase 122'-Pde2-PdeMitochondrial Deadenylase |
| Database Links | Reactome: R-HSA-8983711 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Peptide Names | 2' -5'-Phosphodiesterase 12 protein2'-Pde protein2-Pde proteinMitochondrial Deadenylase proteinPDE12 protein |
Information sourced from Uniprot.org