| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Nurr1 Blocking Peptide is synthetically produced from the 566-591 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
NR4A2 |
| Gene ID: |
4929 |
| Uniprot ID: |
NR4A2_HUMAN |
| Immunogen Region: |
566-591 |
| Immunogen: |
Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence: CTQGLQRIFYLKLEDLVP |
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. |
| Peptide Name | Nuclear Receptor Subfamily 4 Group A Member 2Immediate-Early Response Protein NotOrphan Nuclear Receptor Nurr1Transcriptionally-Inducible Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusMostly NuclearOxidative Stress Promotes Cytoplasmic Localization |
| Alternative Peptide Names | Nuclear Receptor Subfamily 4 Group A Member 2 proteinImmediate-Early Response Protein Not proteinOrphan Nuclear Receptor Nurr1 proteinTranscriptionally-Inducible Nuclear Receptor proteinNR4A2 proteinNOT proteinNURR1 proteinTINUR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
