Nurr1 Blocking Peptide peptide (STJ504433)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence: CTQGLQRIFYLKLEDLVP
General Information
| Short Description | Nurr1 Blocking Peptide is synthetically produced from the 566-591 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | NR4A2 |
| Gene ID | 4929 |
| Uniprot ID | NR4A2_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence: CTQGLQRIFYLKLEDLVP |
| Immunogen Region | 566-591 |
Additional Info
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. |
| Peptide Name | Nuclear Receptor Subfamily 4 Group A Member 2Immediate-Early Response Protein NotOrphan Nuclear Receptor Nurr1Transcriptionally-Inducible Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusMostly NuclearOxidative Stress Promotes Cytoplasmic Localization |
| Alternative Peptide Names | Nuclear Receptor Subfamily 4 Group A Member 2 proteinImmediate-Early Response Protein Not proteinOrphan Nuclear Receptor Nurr1 proteinTranscriptionally-Inducible Nuclear Receptor proteinNR4A2 proteinNOT proteinNURR1 proteinTINUR protein |
Information sourced from Uniprot.org