NTH1 Blocking Peptide is synthetically produced from the 1-100 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
N-epitope synthetic peptide taken within amino acid region 1-100 on human NTHL1 protein.
Immunogen Region
1-100
Additional Info
Tissue Specificity
Widely expressed with highest levels in heart and lowest levels in lung and liver.
Post Translational Modifications
Ubiquitinated by TRIM26.leading to proteasomal degradation.
Function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Peptide Name
Endonuclease Iii-Like Protein 1Hnth1Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site LyaseDna Glycosylase/Ap Lyase
Endonuclease Iii-Like Protein 1 proteinHnth1 proteinBifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase proteinDna Glycosylase/Ap Lyase proteinNTHL1 proteinNTH1 proteinOCTS3 protein
