NTH1 Blocking Peptide peptide (STJ504429)
SPECIFICATIONS
ImmunogenN-epitope synthetic peptide taken within amino acid region 1-100 on human NTHL1 protein.
General Information
| Short Description | NTH1 Blocking Peptide is synthetically produced from the 1-100 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | NTHL1 |
| Gene ID | 4913 |
| Uniprot ID | NTH_HUMAN |
| Immunogen | N-epitope synthetic peptide taken within amino acid region 1-100 on human NTHL1 protein. |
| Immunogen Region | 1-100 |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Peptide Name | Endonuclease Iii-Like Protein 1Hnth1Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site LyaseDna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110357Reactome: R-HSA-9630221Reactome: R-HSA-9630222 |
| Cellular Localisation | NucleusMitochondrion |
| Alternative Peptide Names | Endonuclease Iii-Like Protein 1 proteinHnth1 proteinBifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase proteinDna Glycosylase/Ap Lyase proteinNTHL1 proteinNTH1 proteinOCTS3 protein |
Information sourced from Uniprot.org