Neurochondrin Positive Control for STJ501950 peptide (STJ504485)

Name: Neurochondrin Positive Control for STJ501950 peptide (STJ504485)
SKU: STJ504485-5
Price: 308.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

STJ504485-5

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Short Description	Neurochondrin Positive Control for STJ501950 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications	WB
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	WB: 1:500
Formulation	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	Ncdn
Gene ID	89791
Uniprot ID	NCDN_RAT
Specificity	This is positive control is recommended for use in combination with Neurochondrin antibody STJ501950.

Tissue Specificity	Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.
Post Translational Modifications	Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
Function	Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Peptide Name	Neurochondrin Neurite Outgrowth-Related Protein From The Rat Brain Norbin
Cellular Localisation	Cytoplasm Cytosol Endosome Membrane Lipid-Anchor Cell Projection Dendrite Postsynapse Localizes To Somatic Regions Of Neurons Localization To Endosome Membrane Requires Palmitoylation
Alternative Peptide Names	Neurochondrin protein Neurite Outgrowth-Related Protein From The Rat Brain protein Norbin protein Ncdn protein

Information sourced from Uniprot.org