Neurochondrin Positive Control for STJ501950 peptide (STJ504485)
SPECIFICATIONS
General Information
| Short Description | Neurochondrin Positive Control for STJ501950 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Ncdn |
| Gene ID | 89791 |
| Uniprot ID | NCDN_RAT |
| Specificity | This is positive control is recommended for use in combination with Neurochondrin antibody STJ501950. |
Additional Info
| Tissue Specificity | Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites. |
| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. |
| Function | Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. |
| Peptide Name | NeurochondrinNeurite Outgrowth-Related Protein From The Rat BrainNorbin |
| Cellular Localisation | CytoplasmCytosolEndosome MembraneLipid-AnchorCell ProjectionDendritePostsynapseLocalizes To Somatic Regions Of NeuronsLocalization To Endosome Membrane Requires Palmitoylation |
| Alternative Peptide Names | Neurochondrin proteinNeurite Outgrowth-Related Protein From The Rat Brain proteinNorbin proteinNcdn protein |
Information sourced from Uniprot.org