Neurochondrin Blocking Peptide for STJ501950 peptide (STJ504422)

Name: Neurochondrin Blocking Peptide for STJ501950 peptide (STJ504422)
SKU: STJ504422-250
Price: 260.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

ImmunogenSynthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein.

STJ504422-250

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Short Description	Neurochondrin Blocking Peptide for STJ501950 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	Ncdn
Gene ID	89791
Uniprot ID	NCDN_RAT
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein.
Specificity	This blocking peptide is recommended for use in combination with Neurochondrin antibody, STJ501950

Tissue Specificity	Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.
Post Translational Modifications	Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
Function	Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Peptide Name	Neurochondrin Neurite Outgrowth-Related Protein From The Rat Brain Norbin
Cellular Localisation	Cytoplasm Cytosol Endosome Membrane Lipid-Anchor Cell Projection Dendrite Postsynapse Localizes To Somatic Regions Of Neurons Localization To Endosome Membrane Requires Palmitoylation
Alternative Peptide Names	Neurochondrin protein Neurite Outgrowth-Related Protein From The Rat Brain protein Norbin protein Ncdn protein

Information sourced from Uniprot.org